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Molecular Biology of Human Cancers: An Advanced Student's Textbook
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Binding: Hardcover
Dewey Decimal Number: 616.994042
EAN: 9781402031854
Edition: 1
ISBN: 1402031858
Label: Springer
Manufacturer: Springer
Number Of Items: 1
Number Of Pages: 508
Publication Date: April 29, 2005
Publisher: Springer
Studio: Springer
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Editorial Review:Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer.
Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis.
A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point.
In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III.
More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Customer Reviews
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Rating: - Highly recommended
This text is higly informative and readable. Highly recommended for a student of the biology of human cancers. This advanced text gives an overview of the broad range of signaling pathways and mechanisms involved in the formation and progression of tumors. Suitable for graduate students before they embark on a journey exploring the molecular complexities of cancer. Excellent preparatory text for beginning basic science researchers or clinicians who wish to embark cancer research.
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